Comment on: Visinoni et al. The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity. Diabetes 2012;61:1122–1132

  1. Andrea Masotti
  1. From the Gene Expression–Microarrays Laboratory, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
  1. Corresponding author: Andrea Masotti, andrea.masotti{at}

In the May 2012 issue of Diabetes, Visinoni et al. (1) described the role of liver fructose-1,6-bisphosphatase (FBP-1) in regulating appetite and adiposity and in contributing to body weight regulation. In transgenic mice overexpressing FBP-1, they observed a lean body weight phenotype and ∼50% reduction of adiposity that was supported by a reduction of food intake. In keeping with this evidence, appetite-stimulating neuropeptide Y and Agouti-related peptide were found to be significantly suppressed. The authors observed an inversion of the lean body weight phenotype by pharmacologic inhibition of FBP-1, suggesting a crucial role for this enzyme in the presence of excess nutrients/fats. FBP-1 is an enzyme in …

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