Table of Contents

Commentaries

Select this article
- James R. Sowers
Role of TRIB3 in Diabetic and Overnutrition-Induced Atherosclerosis
Diabetes February 2012 61:265-266; doi:10.2337/db11-1495
Select this article
- Mark J. Holness and
- Mary C. Sugden
Damaging Loss of Self-Control by Stressed β-Cells
Diabetes February 2012 61:267-269; doi:10.2337/db11-1647
Select this article
- Ananda Basu,
- Morten Gram Pedersen,
- and Claudio Cobelli
Prediabetes: Evaluation of β-Cell Function
Diabetes February 2012 61:270-271; doi:10.2337/db11-1677

Novel Methodologies

Select this article
- Eijiro Yamada and
- Rajat Singh
Mapping Autophagy on to Your Metabolic Radar
Diabetes February 2012 61:272-280; doi:10.2337/db11-1199

Metabolism

Select this article
- José María Moreno-Navarrete,
- Victoria Catalán,
- Lauren Whyte,
- Adenis Díaz-Arteaga,
- Rafael Vázquez-Martínez,
- Fernando Rotellar,
- Rocío Guzmán,
- Javier Gómez-Ambrosi,
- Marina R. Pulido,
- Wendy R. Russell,
- Mónica Imbernón,
- Ruth A. Ross,
- María M. Malagón,
- Carlos Dieguez,
- José Manuel Fernández-Real,
- Gema Frühbeck,
- and Ruben Nogueiras
The l-α-Lysophosphatidylinositol/GPR55 System and Its Potential Role in Human Obesity
Diabetes February 2012 61:281-291; published ahead of print December 16, 2011, doi:10.2337/db11-0649
Select this article
- Özlem Gögebakan,
- Janin Andres,
- Katrin Biedasek,
- Knut Mai,
- Peter Kühnen,
- Heiko Krude,
- Frank Isken,
- Natalia Rudovich,
- Martin A. Osterhoff,
- Ulrich Kintscher,
- Michael Nauck,
- Andreas F.H. Pfeiffer,
- and Joachim Spranger
Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids
Diabetes February 2012 61:292-300; published ahead of print December 16, 2011, doi:10.2337/db10-0902
Select this article
- Florencia Halperin,
- Ximena Lopez,
- Raquel Manning,
- C. Ronald Kahn,
- Rohit N. Kulkarni,
- and Allison B. Goldfine
Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans
Diabetes February 2012 61:301-309; doi:10.2337/db11-1067
Select this article
- Camille Attané,
- Camille Foussal,
- Sophie Le Gonidec,
- Alexandre Benani,
- Danièle Daviaud,
- Estelle Wanecq,
- Rocío Guzmán-Ruiz,
- Cédric Dray,
- Veronic Bezaire,
- Chloé Rancoule,
- Keiji Kuba,
- Mariano Ruiz-Gayo,
- Thierry Levade,
- Josef Penninger,
- Rémy Burcelin,
- Luc Pénicaud,
- Philippe Valet,
- and Isabelle Castan-Laurell
Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice
Diabetes February 2012 61:310-320; published ahead of print December 30, 2011, doi:10.2337/db11-0100
Select this article
- Mayowa A. Osundiji,
- Daniel D. Lam,
- Jill Shaw,
- Chen-Yu Yueh,
- S. Pauliina Markkula,
- Paul Hurst,
- Carolina Colliva,
- Aldo Roda,
- Lora K. Heisler,
- and Mark L. Evans
Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion
Diabetes February 2012 61:321-328; published ahead of print December 30, 2011, doi:10.2337/db11-1050
Select this article
- Christina Koutsari,
- Manpreet S. Mundi,
- Asem H. Ali,
- and Michael D. Jensen
Storage Rates of Circulating Free Fatty Acid Into Adipose Tissue During Eating or Walking in Humans
Diabetes February 2012 61:329-338; published ahead of print January 6, 2012, doi:10.2337/db11-0748
Select this article
- Chun-Xia Yi,
- Ewout Foppen,
- William Abplanalp,
- Yuanqing Gao,
- Anneke Alkemade,
- Susanne E. la Fleur,
- Mireille J. Serlie,
- Eric Fliers,
- Ruud M. Buijs,
- Matthias H. Tschöp,
- and Andries Kalsbeek
Glucocorticoid Signaling in the Arcuate Nucleus Modulates Hepatic Insulin Sensitivity
Diabetes February 2012 61:339-345; published ahead of print December 30, 2011, doi:10.2337/db11-1239
Select this article
- Da Young Oh,
- Hidetaka Morinaga,
- Saswata Talukdar,
- Eun Ju Bae,
- and Jerrold M. Olefsky
Increased Macrophage Migration Into Adipose Tissue in Obese Mice
Diabetes February 2012 61:346-354; published ahead of print December 21, 2011, doi:10.2337/db11-0860
Select this article
- Caleb C. Lord,
- Jenna L. Betters,
- Pavlina T. Ivanova,
- Stephen B. Milne,
- David S. Myers,
- Jennifer Madenspacher,
- Gwynneth Thomas,
- Soonkyu Chung,
- Mingxia Liu,
- Matthew A. Davis,
- Richard G. Lee,
- Rosanne M. Crooke,
- Mark J. Graham,
- John S. Parks,
- Dawn L. Brasaemle,
- Michael B. Fessler,
- H. Alex Brown,
- and J. Mark Brown
CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action
Diabetes February 2012 61:355-363; published ahead of print January 6, 2012, doi:10.2337/db11-0994

Signal Transduction

Select this article
- Gwen Tolhurst,
- Helen Heffron,
- Yu Shan Lam,
- Helen E. Parker,
- Abdella M. Habib,
- Eleftheria Diakogiannaki,
- Jennifer Cameron,
- Johannes Grosse,
- Frank Reimann,
- and Fiona M. Gribble
Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2
Diabetes February 2012 61:364-371; published ahead of print December 21, 2011, doi:10.2337/db11-1019

Obesity Studies

Select this article
- Rafael Simó,
- Anna Barbosa-Desongles,
- Albert Lecube,
- Cristina Hernandez,
- and David M. Selva
Potential Role of Tumor Necrosis Factor-α in Downregulating Sex Hormone–Binding Globulin
Diabetes February 2012 61:372-382; published ahead of print December 30, 2011, doi:10.2337/db11-0727
Select this article
- John W.M. Creemers,
- Hélène Choquet,
- Pieter Stijnen,
- Vincent Vatin,
- Marie Pigeyre,
- Sigri Beckers,
- Sandra Meulemans,
- Manuel E. Than,
- Loïc Yengo,
- Maithé Tauber,
- Beverley Balkau,
- Paul Elliott,
- Marjo-Riitta Jarvelin,
- Wim Van Hul,
- Luc Van Gaal,
- Fritz Horber,
- François Pattou,
- Philippe Froguel,
- and David Meyre
Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity
Diabetes February 2012 61:383-390; published ahead of print December 30, 2011, doi:10.2337/db11-0305
Select this article
- Alexandra Groom,
- Catherine Potter,
- Daniel C. Swan,
- Ghazaleh Fatemifar,
- David M. Evans,
- Susan M. Ring,
- Valerie Turcot,
- Mark S. Pearce,
- Nicholas D. Embleton,
- George Davey Smith,
- John C. Mathers,
- and Caroline L. Relton
Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the TACSTD2 Gene and Childhood Fat Mass
Diabetes February 2012 61:391-400; published ahead of print December 21, 2011, doi:10.2337/db11-1039
Select this article
- Kim van der Weerd,
- Willem A. Dik,
- Benjamin Schrijver,
- Dave H. Schweitzer,
- Anton W. Langerak,
- Hemmo A. Drexhage,
- Rosalie M. Kiewiet,
- Maarten O. van Aken,
- Astrid van Huisstede,
- Jacques J.M. van Dongen,
- Aart-Jan van der Lelij,
- Frank J.T. Staal,
- and P. Martin van Hagen
Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4⁺ T Cells With Skewing Toward a Treg- and Th2-Dominated Phenotype
Diabetes February 2012 61:401-408; published ahead of print January 6, 2012, doi:10.2337/db11-1065

Islet Studies

Select this article
- Latif Rachdi,
- Virginie Aïello,
- Bertrand Duvillié,
- and Raphaël Scharfmann
l-Leucine Alters Pancreatic β-Cell Differentiation and Function via the mTor Signaling Pathway
Diabetes February 2012 61:409-417; published ahead of print December 30, 2011, doi:10.2337/db11-0765
Select this article
- Karen K. Takane,
- Jeffery W. Kleinberger,
- Fatimah G. Salim,
- Nathalie M. Fiaschi-Taesch,
- and Andrew F. Stewart
Regulated and Reversible Induction of Adult Human β-Cell Replication
Diabetes February 2012 61:418-424; published ahead of print December 30, 2011, doi:10.2337/db11-0580

Immunology and Transplantation

Select this article
- Balasubramanian Krishnamurthy,
- Jonathan Chee,
- Gaurang Jhala,
- Stacey Fynch,
- Kate L. Graham,
- Pere Santamaria,
- Grant Morahan,
- Janette Allison,
- David Izon,
- Helen E. Thomas,
- and Thomas W.H. Kay
Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
Diabetes February 2012 61:425-435; published ahead of print December 21, 2011, doi:10.2337/db11-0948
Select this article
- Suparna A. Sarkar,
- Catherine E. Lee,
- Francisco Victorino,
- Tom T. Nguyen,
- Jay A. Walters,
- Adam Burrack,
- Jens Eberlein,
- Steven K. Hildemann,
- and Dirk Homann
Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes
Diabetes February 2012 61:436-446; published ahead of print December 30, 2011, doi:10.2337/db11-0853

Pathophysiology

Select this article
- Mustafa Kanat,
- Andrea Mari,
- Luke Norton,
- Diedre Winnier,
- Ralph A. DeFronzo,
- Chris Jenkinson,
- and Muhammad A. Abdul-Ghani
Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance
Diabetes February 2012 61:447-453; doi:10.2337/db11-0995
Select this article
- Rossella Menghini,
- Viviana Casagrande,
- Stefano Menini,
- Arianna Marino,
- Valeria Marzano,
- Marta L. Hribal,
- Paolo Gentileschi,
- Davide Lauro,
- Orazio Schillaci,
- Giuseppe Pugliese,
- Paolo Sbraccia,
- Andrea Urbani,
- Renato Lauro,
- and Massimo Federici
TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver Disease in Mice
Diabetes February 2012 61:454-462; published ahead of print January 6, 2012, doi:10.2337/db11-0613

Complications

Select this article
- Zhi-hao Wang,
- Yuan-yuan Shang,
- Shun Zhang,
- Ming Zhong,
- Xu-ping Wang,
- Jing-ti Deng,
- Jie Pan,
- Yun Zhang,
- and Wei Zhang
Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE^−/−/LDL Receptor^−/− Mice
Diabetes February 2012 61:463-473; doi:10.2337/db11-0518
Select this article
- Garnet J. Lau,
- Nicolas Godin,
- Hasna Maachi,
- Chao-Sheng Lo,
- Shyh-Jong Wu,
- Jian-Xin Zhu,
- Marie-Luise Brezniceanu,
- Isabelle Chénier,
- Joelle Fragasso-Marquis,
- Jean-Baptiste Lattouf,
- Jean Ethier,
- Janos G. Filep,
- Julie R. Ingelfinger,
- Viji Nair,
- Matthias Kretzler,
- Clemens D. Cohen,
- Shao-Ling Zhang,
- and John S.D. Chan
Bcl-2–Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice
Diabetes February 2012 61:474-484; published ahead of print December 30, 2011, doi:10.2337/db11-0141
Select this article
- Ansgar S. Olsen,
- Michael P. Sarras, Jr.,
- Alexey Leontovich,
- and Robert V. Intine
Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression
Diabetes February 2012 61:485-491; published ahead of print January 6, 2012, doi:10.2337/db11-0588
Select this article
- Yimin Zhong,
- Jingming Li,
- Yanming Chen,
- Joshua J. Wang,
- Rajiv Ratan,
- and Sarah X. Zhang
Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Müller Cell–Derived Inflammatory Cytokine Production in Diabetes
Diabetes February 2012 61:492-504; published ahead of print January 6, 2012, doi:10.2337/db11-0315

Pharmacology and Therapeutics

Select this article
- James Mu,
- Jason Pinkstaff,
- Zhihua Li,
- Lillian Skidmore,
- Nina Li,
- Heather Myler,
- Qing Dallas-Yang,
- Anna-Maria Putnam,
- Jun Yao,
- Stuart Bussell,
- Margaret Wu,
- Thea C. Norman,
- Carlos G. Rodriguez,
- Bruce Kimmel,
- Joseph M. Metzger,
- Anthony Manibusan,
- Darin Lee,
- Dennis M. Zaller,
- Bei B. Zhang,
- Richard D. DiMarchi,
- Joel P. Berger,
- and Douglas W. Axelrod
FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
Diabetes February 2012 61:505-512; published ahead of print December 30, 2011, doi:10.2337/db11-0838
Select this article
- Robin Winkler,
- Verena Benz,
- Markus Clemenz,
- Mandy Bloch,
- Anna Foryst-Ludwig,
- Sami Wardat,
- Nicole Witte,
- Manuela Trappiel,
- Pawel Namsolleck,
- Knut Mai,
- Joachim Spranger,
- Gabriele Matthias,
- Tim Roloff,
- Oliver Truee,
- Kai Kappert,
- Michael Schupp,
- Patrick Matthias,
- and Ulrich Kintscher
Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis
Diabetes February 2012 61:513-523; published ahead of print December 30, 2011, doi:10.2337/db11-0313

Genetics/Genomes/Proteomics/Metabolomics

Select this article
- Marcel Marquez,
- Marlène Huyvaert,
- John R.B. Perry,
- Richard D. Pearson,
- Mario Falchi,
- Andrew P. Morris,
- Sidonie Vivequin,
- Stéphane Lobbens,
- Loïc Yengo,
- Stefan Gaget,
- Francois Pattou,
- Odile Poulain-Godefroy,
- Guillaume Charpentier,
- Lena M.S. Carlsson,
- Peter Jacobson,
- Lars Sjöström,
- Olivier Lantieri,
- Barbara Heude,
- Andrew Walley,
- Beverley Balkau,
- Michel Marre,
- the DIAGRAM Consortium,
- Philippe Froguel,
- and Stéphane Cauchi
Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk
Diabetes February 2012 61:524-530; published ahead of print December 30, 2011, doi:10.2337/db11-0728
Select this article
- Soo Heon Kwak,
- Sung-Hoon Kim,
- Young Min Cho,
- Min Jin Go,
- Yoon Shin Cho,
- Sung Hee Choi,
- Min Kyong Moon,
- Hye Seung Jung,
- Hyoung Doo Shin,
- Hyun Min Kang,
- Nam H. Cho,
- In Kyu Lee,
- Seong Yeon Kim,
- Bok-Ghee Han,
- Hak C. Jang,
- and Kyong Soo Park
A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
Diabetes February 2012 61:531-541; published ahead of print January 10, 2012, doi:10.2337/db11-1034
Select this article
- Jinying Zhao,
- Jack Goldberg,
- James D. Bremner,
- and Viola Vaccarino
Global DNA Methylation Is Associated With Insulin Resistance: A Monozygotic Twin Study
Diabetes February 2012 61:542-546; published ahead of print December 30, 2011, doi:10.2337/db11-1048

Issues and Events

Select this article

Issues and Events
Diabetes February 2012 61:547; doi:10.2337/db12-ie02

Diabetes

Commentaries

Role of TRIB3 in Diabetic and Overnutrition-Induced Atherosclerosis

Damaging Loss of Self-Control by Stressed β-Cells

Prediabetes: Evaluation of β-Cell Function

Novel Methodologies

Mapping Autophagy on to Your Metabolic Radar

Metabolism

The l-α-Lysophosphatidylinositol/GPR55 System and Its Potential Role in Human Obesity

Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids

Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans

Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice

Brain Glucose Sensors Play a Significant Role in the Regulation of Pancreatic Glucose-Stimulated Insulin Secretion

Storage Rates of Circulating Free Fatty Acid Into Adipose Tissue During Eating or Walking in Humans

Glucocorticoid Signaling in the Arcuate Nucleus Modulates Hepatic Insulin Sensitivity

Increased Macrophage Migration Into Adipose Tissue in Obese Mice

CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action

Signal Transduction

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2

Obesity Studies

Potential Role of Tumor Necrosis Factor-α in Downregulating Sex Hormone–Binding Globulin

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity

Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the TACSTD2 Gene and Childhood Fat Mass

Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4+ T Cells With Skewing Toward a Treg- and Th2-Dominated Phenotype

Islet Studies

l-Leucine Alters Pancreatic β-Cell Differentiation and Function via the mTor Signaling Pathway

Regulated and Reversible Induction of Adult Human β-Cell Replication

Immunology and Transplantation

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes

Pathophysiology

Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance

TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver Disease in Mice

Complications

Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE−/−/LDL Receptor−/− Mice

Bcl-2–Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice

Heritable Transmission of Diabetic Metabolic Memory in Zebrafish Correlates With DNA Hypomethylation and Aberrant Gene Expression

Activation of Endoplasmic Reticulum Stress by Hyperglycemia Is Essential for Müller Cell–Derived Inflammatory Cytokine Production in Diabetes

Pharmacology and Therapeutics

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents

Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis

Genetics/Genomes/Proteomics/Metabolomics

Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk

A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women

Global DNA Methylation Is Associated With Insulin Resistance: A Monozygotic Twin Study

Issues and Events

Issues and Events

This Issue

Current Issue

Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4⁺ T Cells With Skewing Toward a Treg- and Th2-Dominated Phenotype

Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE^−/−/LDL Receptor^−/− Mice