Skip to main content
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • Standards of Medical Care
    • Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care
  • Subscribe
  • Log in
  • Follow ada on Twitter
  • RSS
  • Visit ada on Facebook
Diabetes

Advanced Search

Main menu

  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
  • Browse
    • By Topic
    • Issue Archive
    • Scientific Sessions Abstracts
  • Info
    • About the Journal
    • Meet the Editors
    • Reprints & Permissions
    • Journal Policies
    • For Authors
    • For Reviewers
    • For Advertisers
  • Subscriptions
    • Manage Online Access
    • Individual Subscriptions
    • Institutional Subscriptions
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Diabetes Discovery
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • Journal Policies
    • Instructions for Authors
    • Peer Review
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • Standards of Medical Care
    • Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care

User menu

  • Subscribe
  • Log in

Search

  • Advanced search
Diabetes
  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
  • Browse
    • By Topic
    • Issue Archive
    • Scientific Sessions Abstracts
  • Info
    • About the Journal
    • Meet the Editors
    • Reprints & Permissions
    • Journal Policies
    • For Authors
    • For Reviewers
    • For Advertisers
  • Subscriptions
    • Manage Online Access
    • Individual Subscriptions
    • Institutional Subscriptions
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Diabetes Discovery
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • Journal Policies
    • Instructions for Authors
    • Peer Review
Pathophysiology

Interbirth Interval Is Associated With Childhood Type 1 Diabetes Risk

  1. Chris R. Cardwell1⇓,
  2. Jannet Svensson2,
  3. Thomas Waldhoer3,
  4. Johnny Ludvigsson4,
  5. Vaiva Sadauskaitė-Kuehne5,
  6. Christine L. Roberts6,
  7. Roger C. Parslow7,
  8. Emma J.K. Wadsworth8,
  9. Girts Brigis9,
  10. Brone Urbonaitė10,
  11. Edith Schober11,
  12. Gabriele Devoti12,
  13. Constantin Ionescu-Tirgoviste13,
  14. Carine E. de Beaufort14,
  15. Gyula Soltesz15 and
  16. Chris C. Patterson1
  1. 1Centre for Public Health, Queen’s University Belfast, Belfast, U.K.
  2. 2Pediatric Department, Glostrup University Hospital, Glostrup, Denmark
  3. 3Department of Epidemiology, Medical University of Vienna, Vienna, Austria
  4. 4Department of Paediatrics and Diabetes Research Centre, Linkoping University, Linkoping, Sweden
  5. 5Institute of Endocrinology of Lithuanian University of Health Science, Kaunas, Lithuania
  6. 6Kolling Institute of Medical Research, University of Sydney, Sydney, Australia
  7. 7Paediatric Epidemiology Group, University of Leeds, Leeds, U.K.
  8. 8Centre for Occupational and Health Psychology, Cardiff University, Cardiff, U.K.
  9. 9Department of Public Health and Epidemiology, Riga Stradins University, Riga, Latvia
  10. 10Institute of Endocrinology, Kaunas University of Medicine, Kaunas, Lithuania
  11. 11Department of Paediatrics, Medical University of Vienna, Vienna, Austria
  12. 12Department of Social Sciences and Communication, University of Lecce, Lecce, Italy
  13. 13Nutrition and Metabolic Diseases Clinic, N. Paulescu Institute of Diabetes, Bucharest, Romania
  14. 14Clinique Pédiatrique Luxembourg, Luxembourg, Luxembourg
  15. 15Department of Pediatrics, University of Pécs, Pécs, Hungary
  1. Corresponding author: Chris R. Cardwell, c.cardwell{at}qub.ac.uk.
Diabetes 2012 Mar; 61(3): 702-707. https://doi.org/10.2337/db11-1000
PreviousNext
  • Article
  • Figures & Tables
  • Info & Metrics
  • PDF
Loading

Abstract

Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals <3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72–0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals <3 years.

  • Received July 18, 2011.
  • Accepted December 9, 2011.
  • © 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

View Full Text
PreviousNext
Back to top
Diabetes: 61 (3)

In this Issue

March 2012, 61(3)
  • Table of Contents
  • About the Cover
  • Index by Author
Sign up to receive current issue alerts
View Selected Citations (0)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about Diabetes.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Interbirth Interval Is Associated With Childhood Type 1 Diabetes Risk
(Your Name) has forwarded a page to you from Diabetes
(Your Name) thought you would like to see this page from the Diabetes web site.
Citation Tools
Interbirth Interval Is Associated With Childhood Type 1 Diabetes Risk
Chris R. Cardwell, Jannet Svensson, Thomas Waldhoer, Johnny Ludvigsson, Vaiva Sadauskaitė-Kuehne, Christine L. Roberts, Roger C. Parslow, Emma J.K. Wadsworth, Girts Brigis, Brone Urbonaitė, Edith Schober, Gabriele Devoti, Constantin Ionescu-Tirgoviste, Carine E. de Beaufort, Gyula Soltesz, Chris C. Patterson
Diabetes Mar 2012, 61 (3) 702-707; DOI: 10.2337/db11-1000

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Add to Selected Citations
Share

Interbirth Interval Is Associated With Childhood Type 1 Diabetes Risk
Chris R. Cardwell, Jannet Svensson, Thomas Waldhoer, Johnny Ludvigsson, Vaiva Sadauskaitė-Kuehne, Christine L. Roberts, Roger C. Parslow, Emma J.K. Wadsworth, Girts Brigis, Brone Urbonaitė, Edith Schober, Gabriele Devoti, Constantin Ionescu-Tirgoviste, Carine E. de Beaufort, Gyula Soltesz, Chris C. Patterson
Diabetes Mar 2012, 61 (3) 702-707; DOI: 10.2337/db11-1000
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • RESEARCH DESIGN AND METHODS
    • RESULTS
    • DISCUSSION
    • ACKNOWLEDGMENTS
    • REFERENCES
  • Figures & Tables
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • PDGF-BB Carried by Endothelial Cell–Derived Extracellular Vesicles Reduces Vascular Smooth Muscle Cell Apoptosis in Diabetes
  • Defective Amplifying Pathway of β-Cell Secretory Response to Glucose in Type 2 Diabetes: Integrated Modeling of In Vitro and In Vivo Evidence
  • Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats
Show more Pathophysiology

Similar Articles

Navigate

  • Current Issue
  • Online Ahead of Print
  • Scientific Sessions Abstracts
  • Collections
  • Archives
  • Submit
  • Subscribe
  • Email Alerts
  • RSS Feeds

More Information

  • About the Journal
  • Instructions for Authors
  • Journal Policies
  • Reprints and Permissions
  • For Advertisers
  • Privacy Policy: ADA Journals
  • Copyright Notice/Public Access Policy
  • Contact Us

Other ADA Resources

  • Diabetes Care
  • Clinical Diabetes
  • Diabetes Spectrum
  • Standards of Medical Care in Diabetes
  • BMJ Open - Diabetes Research & Care
  • Scientific Sessions Abstracts
  • Professional Books
  • Diabetes Forecast

 

  • DiabetesJournals.org
  • Diabetes Core Update
  • ADA's DiabetesPro
  • ADA Member Directory
  • Diabetes.org

© 2018 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.