Table of Contents

Perspectives in Diabetes

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- John Wahren,
- Åsa Kallas,
- and Anders A.F. Sima
The Clinical Potential of C-Peptide Replacement in Type 1 Diabetes
Diabetes April 2012 61:761-772; doi:10.2337/db11-1423

Commentaries

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- Beatrice M. Filippi,
- Patricia I. Mighiu,
- and Tony K.T. Lam
Is Insulin Action in the Brain Clinically Relevant?
Diabetes April 2012 61:773-775; doi:10.2337/db12-0048
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- Colleen M. Novak and
- Chaitanya K. Gavini
Smokeless Weight Loss
Diabetes April 2012 61:776-777; doi:10.2337/db12-0074
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- Roy Taylor
Insulin Resistance and Type 2 Diabetes
Diabetes April 2012 61:778-779; doi:10.2337/db12-0073
Select this article
- Bryan O’Sullivan-Murphy and
- Fumihiko Urano
ER Stress as a Trigger for β-Cell Dysfunction and Autoimmunity in Type 1 Diabetes
Diabetes April 2012 61:780-781; doi:10.2337/db12-0091

Metabolism

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- Manfred Hallschmid,
- Suzanne Higgs,
- Matthias Thienel,
- Volker Ott,
- and Hendrik Lehnert
Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women
Diabetes April 2012 61:782-789; published ahead of print February 16, 2012, doi:10.2337/db11-1390
Select this article
- Mark Nixon,
- Deborah J. Wake,
- Dawn E. Livingstone,
- Roland H. Stimson,
- Cristina L. Esteves,
- Jonathan R. Seckl,
- Karen E. Chapman,
- Ruth Andrew,
- and Brian R. Walker
Salicylate Downregulates 11β-HSD1 Expression in Adipose Tissue in Obese Mice and in Humans, Mediating Insulin Sensitization
Diabetes April 2012 61:790-796; published ahead of print February 22, 2012, doi:10.2337/db11-0931
Select this article
- Huating Li,
- Zhanguo Gao,
- Jin Zhang,
- Xin Ye,
- Aimin Xu,
- Jianping Ye,
- and Weiping Jia
Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3
Diabetes April 2012 61:797-806; published ahead of print February 14, 2012, doi:10.2337/db11-0846

Obesity Studies

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- Pablo B. Martínez de Morentin,
- Andrew J. Whittle,
- Johan Fernø,
- Rubén Nogueiras,
- Carlos Diéguez,
- Antonio Vidal-Puig,
- and Miguel López
Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase
Diabetes April 2012 61:807-817; published ahead of print February 7, 2012, doi:10.2337/db11-1079

Islet Studies

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- Sarah A. Tersey,
- Yurika Nishiki,
- Andrew T. Templin,
- Susanne M. Cabrera,
- Natalie D. Stull,
- Stephanie C. Colvin,
- Carmella Evans-Molina,
- Jenna L. Rickus,
- Bernhard Maier,
- and Raghavendra G. Mirmira
Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
Diabetes April 2012 61:818-827; doi:10.2337/db11-1293
Select this article
- Ming Liu,
- Roberto Lara-Lemus,
- Shu-ou Shan,
- Jordan Wright,
- Leena Haataja,
- Fabrizio Barbetti,
- Huan Guo,
- Dennis Larkin,
- and Peter Arvan
Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes
Diabetes April 2012 61:828-837; published ahead of print February 22, 2012, doi:10.2337/db11-0878
Select this article
- Tatsuya Kondo,
- Kazunari Sasaki,
- Rina Matsuyama,
- Saori Morino-Koga,
- Hironori Adachi,
- Mary Ann Suico,
- Junji Kawashima,
- Hiroyuki Motoshima,
- Noboru Furukawa,
- Hirofumi Kai,
- and Eiichi Araki
Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis
Diabetes April 2012 61:838-847; published ahead of print February 23, 2012, doi:10.2337/db11-1098
Select this article
- Guanlan Xu,
- Junqin Chen,
- Gu Jing,
- and Anath Shalev
Preventing β-Cell Loss and Diabetes With Calcium Channel Blockers
Diabetes April 2012 61:848-856; doi:10.2337/db11-0955

Immunology and Transplantation

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- Maki Nakayama,
- Todd Castoe,
- Tomasz Sosinowski,
- XiangLing He,
- Kelly Johnson,
- Kathryn Haskins,
- Dario A.A. Vignali,
- Laurent Gapin,
- David Pollock,
- and George S. Eisenbarth
Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice
Diabetes April 2012 61:857-865; published ahead of print February 7, 2012, doi:10.2337/db11-1113
Select this article
- Shinae Kang,
- Ho Seon Park,
- Anna Jo,
- Shin Hee Hong,
- Han Na Lee,
- Yeon Yi Lee,
- Joong Shin Park,
- Hye Seung Jung,
- Sung Soo Chung,
- and Kyong Soo Park
Endothelial Progenitor Cell Cotransplantation Enhances Islet Engraftment by Rapid Revascularization
Diabetes April 2012 61:866-876; published ahead of print February 23, 2012, doi:10.2337/db10-1492

Pathophysiology

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- Katsutaro Morino,
- Kitt Falk Petersen,
- Saki Sono,
- Cheol Soo Choi,
- Varman T. Samuel,
- Aiping Lin,
- Amy Gallo,
- Hongyu Zhao,
- Atsunori Kashiwagi,
- Ira J. Goldberg,
- Hong Wang,
- Robert H. Eckel,
- Hiroshi Maegawa,
- and Gerald I. Shulman
Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes
Diabetes April 2012 61:877-887; published ahead of print February 24, 2012, doi:10.2337/db11-1391
Select this article
- Weidong Chai,
- Zhenhua Dong,
- Nasui Wang,
- Wenhui Wang,
- Lijian Tao,
- Wenhong Cao,
- and Zhenqi Liu
Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide–Dependent Mechanism
Diabetes April 2012 61:888-896; published ahead of print February 22, 2012, doi:10.2337/db11-1073

Complications

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- Satoshi Miyamoto,
- Kenichi Shikata,
- Kyoko Miyasaka,
- Shinichi Okada,
- Motofumi Sasaki,
- Ryo Kodera,
- Daisho Hirota,
- Nobuo Kajitani,
- Tetsuharu Takatsuka,
- Hitomi Usui Kataoka,
- Shingo Nishishita,
- Chikage Sato,
- Akihiro Funakoshi,
- Hisakazu Nishimori,
- Haruhito Adam Uchida,
- Daisuke Ogawa,
- and Hirofumi Makino
Cholecystokinin Plays a Novel Protective Role in Diabetic Kidney Through Anti-inflammatory Actions on Macrophage: Anti-inflammatory Effect of Cholecystokinin
Diabetes April 2012 61:897-907; published ahead of print February 22, 2012, doi:10.2337/db11-0402
Select this article
- Gianpaolo Zerbini,
- Anna Maestroni,
- Alessio Palini,
- Gemma Tremolada,
- Rosangela Lattanzio,
- Silvia Maestroni,
- Matteo Rocco Pastore,
- Antonio Secchi,
- Riccardo Bonfanti,
- Chiara Gerhardinger,
- and Mara Lorenzi
Endothelial Progenitor Cells Carrying Monocyte Markers Are Selectively Abnormal in Type 1 Diabetic Patients With Early Retinopathy
Diabetes April 2012 61:908-914; published ahead of print February 14, 2012, doi:10.2337/db11-1197
Select this article
- Adil Rajwani,
- Vivienne Ezzat,
- Jessica Smith,
- Nadira Y. Yuldasheva,
- Edward R. Duncan,
- Matthew Gage,
- Richard M. Cubbon,
- Matthew B. Kahn,
- Helen Imrie,
- Afroze Abbas,
- Hema Viswambharan,
- Amir Aziz,
- Piruthivi Sukumar,
- Antonio Vidal-Puig,
- Jaswinder K. Sethi,
- Shouhong Xuan,
- Ajay M. Shah,
- Peter J. Grant,
- Karen E. Porter,
- Mark T. Kearney,
- and Stephen B. Wheatcroft
Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis
Diabetes April 2012 61:915-924; published ahead of print February 22, 2012, doi:10.2337/db11-0963
Select this article
- Narumi Hashikawa-Hobara,
- Naoya Hashikawa,
- Yusuke Inoue,
- Hitomi Sanda,
- Yoshito Zamami,
- Shingo Takatori,
- and Hiromu Kawasaki
Candesartan Cilexetil Improves Angiotensin II Type 2 Receptor–Mediated Neurite Outgrowth via the PI3K-Akt Pathway in Fructose-Induced Insulin-Resistant Rats
Diabetes April 2012 61:925-932; published ahead of print February 22, 2012, doi:10.2337/db11-1468

Pharmacology and Therapeutics

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- Hai-Lu Zhao,
- Yi Sui,
- Chun-Feng Qiao,
- Kevin Y. Yip,
- Ross K.K. Leung,
- Stephen K.W. Tsui,
- Heung-Man Lee,
- Harriet K.T. Wong,
- Xun Zhu,
- Jennifer J. Siu,
- Lan He,
- Jing Guan,
- Li-Zhong Liu,
- Hong-Xi Xu,
- Peter C.Y. Tong,
- and Juliana C.N. Chan
Sustained Antidiabetic Effects of a Berberine-Containing Chinese Herbal Medicine Through Regulation of Hepatic Gene Expression
Diabetes April 2012 61:933-943; published ahead of print March 6, 2012, doi:10.2337/db11-1164
Select this article
- Antonio Cittadini,
- Raffaele Napoli,
- Maria Gaia Monti,
- Domenica Rea,
- Salvatore Longobardi,
- Paolo Antonio Netti,
- Marion Walser,
- Mariateresa Samà,
- Gianluca Aimaretti,
- Jörgen Isgaard,
- and Luigi Saccà
Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model
Diabetes April 2012 61:944-953; published ahead of print February 16, 2012, doi:10.2337/db11-1132

Genetics/Genomes/Proteomics/Metabolomics

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- Regine Bergholdt,
- Caroline Brorsson,
- Albert Palleja,
- Lukas A. Berchtold,
- Tina Fløyel,
- Claus Heiner Bang-Berthelsen,
- Klaus Stensgaard Frederiksen,
- Lars Juhl Jensen,
- Joachim Størling,
- and Flemming Pociot
Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
Diabetes April 2012 61:954-962; published ahead of print February 16, 2012, doi:10.2337/db11-1263
Select this article
- Johanna Lempainen,
- Robert Hermann,
- Riitta Veijola,
- Olli Simell,
- Mikael Knip,
- and Jorma Ilonen
Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of β-Cell Autoimmunity
Diabetes April 2012 61:963-966; published ahead of print February 22, 2012, doi:10.2337/db11-0386

Erratum

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Erratum
Diabetes April 2012 61:967; doi:10.2337/db12-er04

Issues and Events

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Issues and Events
Diabetes April 2012 61:968; doi:10.2337/db12-ie04

Diabetes

Perspectives in Diabetes

The Clinical Potential of C-Peptide Replacement in Type 1 Diabetes

Commentaries

Is Insulin Action in the Brain Clinically Relevant?

Smokeless Weight Loss

Insulin Resistance and Type 2 Diabetes

ER Stress as a Trigger for β-Cell Dysfunction and Autoimmunity in Type 1 Diabetes

Metabolism

Postprandial Administration of Intranasal Insulin Intensifies Satiety and Reduces Intake of Palatable Snacks in Women

Salicylate Downregulates 11β-HSD1 Expression in Adipose Tissue in Obese Mice and in Humans, Mediating Insulin Sensitization

Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3

Obesity Studies

Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase

Islet Studies

Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes

Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis

Preventing β-Cell Loss and Diabetes With Calcium Channel Blockers

Immunology and Transplantation

Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice

Endothelial Progenitor Cell Cotransplantation Enhances Islet Engraftment by Rapid Revascularization

Pathophysiology

Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes

Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide–Dependent Mechanism

Complications

Cholecystokinin Plays a Novel Protective Role in Diabetic Kidney Through Anti-inflammatory Actions on Macrophage: Anti-inflammatory Effect of Cholecystokinin

Endothelial Progenitor Cells Carrying Monocyte Markers Are Selectively Abnormal in Type 1 Diabetic Patients With Early Retinopathy

Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis

Candesartan Cilexetil Improves Angiotensin II Type 2 Receptor–Mediated Neurite Outgrowth via the PI3K-Akt Pathway in Fructose-Induced Insulin-Resistant Rats

Pharmacology and Therapeutics

Sustained Antidiabetic Effects of a Berberine-Containing Chinese Herbal Medicine Through Regulation of Hepatic Gene Expression

Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model

Genetics/Genomes/Proteomics/Metabolomics

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of β-Cell Autoimmunity

Erratum

Erratum

Issues and Events

Issues and Events

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