Diabetes: 61 (5)

May 01 2012; volume 61 issue 5

Perspectives in Diabetes

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β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?
Frans Schuit, Leentje Van Lommel, Mikaela Granvik, Lotte Goyvaerts, Geoffroy de Faudeur, Anica Schraenen and Katleen Lemaire

Diabetes 2012 May; 61 (5): 969-975. https://doi.org/10.2337/db11-1564

Commentaries

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Paradigm Shift or Shifting Paradigm for Type 1 Diabetes
Maki Nakayama and George S. Eisenbarth

Diabetes 2012 May; 61 (5): 976-978. https://doi.org/10.2337/db12-0057
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PGC-1α: The Missing Ingredient for Mesenchymal Stem Cell–Mediated Angiogenesis
Willa A. Hsueh and Anisha A. Gupte

Diabetes 2012 May; 61 (5): 979-980. https://doi.org/10.2337/db12-0078
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Challenges of Linking Early-Life Conditions and Disease Susceptibility
Francine H. Einstein

Diabetes 2012 May; 61 (5): 981-982. https://doi.org/10.2337/db12-0087
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Do Acute Exercise and Diet Reveal the Molecular Basis for Metabolic Flexibility in Skeletal Muscle?
Bret H. Goodpaster and Paul M. Coen

Diabetes 2012 May; 61 (5): 983. https://doi.org/10.2337/db12-0152
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Selective Insulin Receptor Modulators (SIRM): A New Class of Antidiabetes Drugs?
Riccardo Vigneri, Sebastiano Squatrito and Lucia Frittitta

Diabetes 2012 May; 61 (5): 984-985. https://doi.org/10.2337/db12-0192
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GLP-1–Based Therapies and the Exocrine Pancreas: More Light, or Just More Heat?
Edwin A.M. Gale

Diabetes 2012 May; 61 (5): 986-988. https://doi.org/10.2337/db11-1838
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GLP-1 Receptor Agonist Effects on Normal and Neoplastic Pancreata
Michael Goggins

Diabetes 2012 May; 61 (5): 989-990. https://doi.org/10.2337/db12-0233
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Mitochondria, Diabetes, and Alzheimer’s Disease
Margherita Milone

Diabetes 2012 May; 61 (5): 991-992. https://doi.org/10.2337/db12-0209
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A Sweet New Role for Ubiquitin-Specific Protease 2 in Controlling Hepatic Gluconeogenesis
Brian N. Finck

Diabetes 2012 May; 61 (5): 993-994. https://doi.org/10.2337/db12-0198

Methodology Review

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A Novel Method to Measure Glucose Uptake and Myosin Heavy Chain Isoform Expression of Single Fibers From Rat Skeletal Muscle
James G. MacKrell and Gregory D. Cartee

Diabetes 2012 May; 61 (5): 995-1003. https://doi.org/10.2337/db11-1299

Metabolism

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Concordance of Changes in Metabolic Pathways Based on Plasma Metabolomics and Skeletal Muscle Transcriptomics in Type 1 Diabetes
Tumpa Dutta, High Seng Chai, Lawrence E. Ward, Aditya Ghosh, Xuan-Mai T. Persson, G. Charles Ford, Yogish C. Kudva, Zhifu Sun, Yan W. Asmann, Jean-Pierre A. Kocher and K. Sreekumaran Nair

Diabetes 2012 May; 61 (5): 1004-1016. https://doi.org/10.2337/db11-0874
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The Role of FOXO and PPAR Transcription Factors in Diet-Mediated Inhibition of PDC Activation and Carbohydrate Oxidation During Exercise in Humans and the Role of Pharmacological Activation of PDC in Overriding These Changes
Dumitru Constantin-Teodosiu, Despina Constantin, Francis Stephens, David Laithwaite and Paul L. Greenhaff

Diabetes 2012 May; 61 (5): 1017-1024. https://doi.org/10.2337/db11-0799
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Ubiquitin-Specific Protease 2 Regulates Hepatic Gluconeogenesis and Diurnal Glucose Metabolism Through 11β-Hydroxysteroid Dehydrogenase 1
Matthew M. Molusky, Siming Li, Di Ma, Lei Yu and Jiandie D. Lin

Diabetes 2012 May; 61 (5): 1025-1035. https://doi.org/10.2337/db11-0970
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Calorie Restriction Reduces the Influence of Glucoregulatory Dysfunction on Regional Brain Volume in Aged Rhesus Monkeys
Auriel A. Willette, Barbara B. Bendlin, Ricki J. Colman, Erik K. Kastman, Aaron S. Field, Andrew L. Alexander, Aadhavi Sridharan, David B. Allison, Rozalyn Anderson, Mary-Lou Voytko, Joseph W. Kemnitz, Richard H. Weindruch and Sterling C. Johnson

Diabetes 2012 May; 61 (5): 1036-1042. https://doi.org/10.2337/db11-1187
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Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System
Eveline Bruinstroop, Lei Pei, Mariëtte T. Ackermans, Ewout Foppen, Anke J. Borgers, Joan Kwakkel, Anneke Alkemade, Eric Fliers and Andries Kalsbeek

Diabetes 2012 May; 61 (5): 1043-1050. https://doi.org/10.2337/db11-1142
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Loss of AMP-Activated Protein Kinase-α2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle
Pei Wang, Ruo-Yu Zhang, Jie Song, Yun-Feng Guan, Tian-Ying Xu, Hui Du, Benoit Viollet and Chao-Yu Miao

Diabetes 2012 May; 61 (5): 1051-1061. https://doi.org/10.2337/db11-1180
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Liver X Receptor α Is Involved in the Transcriptional Regulation of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Gene
Li-Feng Zhao, Yasumasa Iwasaki, Mitsuru Nishiyama, Takafumi Taguchi, Makoto Tsugita, Mizuho Okazaki, Shuichi Nakayama, Machiko Kambayashi, Shimpei Fujimoto, Koshi Hashimoto, Koji Murao and Yoshio Terada

Diabetes 2012 May; 61 (5): 1062-1071. https://doi.org/10.2337/db11-1255
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Deletion of the Androgen Receptor in Adipose Tissue in Male Mice Elevates Retinol Binding Protein 4 and Reveals Independent Effects on Visceral Fat Mass and on Glucose Homeostasis
Kerry J. McInnes, Lee B. Smith, Nicole I. Hunger, Philippa T.K. Saunders, Ruth Andrew and Brian R. Walker

Diabetes 2012 May; 61 (5): 1072-1081. https://doi.org/10.2337/db11-1136
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Diabetes-Associated Common Genetic Variation and Its Association With GLP-1 Concentrations and Response to Exogenous GLP-1
Galina Smushkin, Matheni Sathananthan, Airani Sathananthan, Chiara Dalla Man, Francesco Micheletto, Alan R. Zinsmeister, Claudio Cobelli and Adrian Vella

Diabetes 2012 May; 61 (5): 1082-1089. https://doi.org/10.2337/db11-1732

Signal Transduction

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GLUT4 and Glycogen Synthase Are Key Players in Bed Rest–Induced Insulin Resistance
Rasmus S. Biensø, Stine Ringholm, Kristian Kiilerich, Niels-Jacob Aachmann-Andersen, Rikke Krogh-Madsen, Borja Guerra, Peter Plomgaard, Gerrit van Hall, Jonas T. Treebak, Bengt Saltin, Carsten Lundby, Jose A.L. Calbet, Henriette Pilegaard and Jørgen F.P. Wojtaszewski

Diabetes 2012 May; 61 (5): 1090-1099. https://doi.org/10.2337/db11-0884
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HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking
Jannick Pétremand, Julien Puyal, Jean-Yves Chatton, Jessica Duprez, Florent Allagnat, Miguel Frias, Richard W. James, Gérard Waeber, Jean-Christophe Jonas and Christian Widmann

Diabetes 2012 May; 61 (5): 1100-1111. https://doi.org/10.2337/db11-1221

Obesity Studies

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Retinoic Acid Upregulates Preadipocyte Genes to Block Adipogenesis and Suppress Diet-Induced Obesity
Daniel C. Berry, David DeSantis, Hooman Soltanian, Colleen M. Croniger and Noa Noy

Diabetes 2012 May; 61 (5): 1112-1121. https://doi.org/10.2337/db11-1620
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The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity
Sherley Visinoni, Nurul Fathiah Izzati Khalid, Christos N. Joannides, Arthur Shulkes, Mildred Yim, Jon Whitehead, Tony Tiganis, Benjamin J. Lamont, Jenny M. Favaloro, Joseph Proietto, Sofianos Andrikopoulos and Barbara C. Fam

Diabetes 2012 May; 61 (5): 1122-1132. https://doi.org/10.2337/db11-1511

Islet Studies

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Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia
Guo-Lian Ding, Fang-Fang Wang, Jing Shu, Shen Tian, Ying Jiang, Dan Zhang, Ning Wang, Qiong Luo, Yu Zhang, Fan Jin, Peter C.K. Leung, Jian-Zhong Sheng and He-Feng Huang

Diabetes 2012 May; 61 (5): 1133-1142. https://doi.org/10.2337/db11-1314
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Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus
Cem Demirci, Sara Ernst, Juan C. Alvarez-Perez, Taylor Rosa, Shelley Valle, Varsha Shridhar, Gabriella P. Casinelli, Laura C. Alonso, Rupangi C. Vasavada and Adolfo García-Ocana

Diabetes 2012 May; 61 (5): 1143-1152. https://doi.org/10.2337/db11-1154

Immunology and Transplantation

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Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α (PGC-1α) Enhances Engraftment and Angiogenesis of Mesenchymal Stem Cells in Diabetic Hindlimb Ischemia
Debin Lu, Ling Zhang, Haihui Wang, Yan Zhang, Jian Liu, Jing Xu, Ziwen Liang, Wuquan Deng, Youzhao Jiang, Qinan Wu, Shufa Li, Zhihua Ai, Yuxu Zhong, Ying Ying, Hongyan Liu, Feng Gao, Zhonghui Zhang and Bing Chen

Diabetes 2012 May; 61 (5): 1153-1159. https://doi.org/10.2337/db11-1271
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Prevention of Type 1 Diabetes in the Rat With an Allele-Specific Anti–T-Cell Receptor AntibodyVβ13 as a Therapeutic Target and Biomarker
Zhijun Liu, Laura Cort, Ryan Eberwine, Thomas Herrmann, Jean H. Leif, Dale L. Greiner, Barak Yahalom, Elizabeth P. Blankenhorn and John P. Mordes

Diabetes 2012 May; 61 (5): 1160-1168. https://doi.org/10.2337/db11-0867
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Following the Fate of One Insulin-Reactive CD4 T cellConversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice
Georgia Fousteri, Jean Jasinski, Amy Dave, Maki Nakayama, Philippe Pagni, Florence Lambolez, Therese Juntti, Ghanashyam Sarikonda, Yang Cheng, Michael Croft, Hilde Cheroutre, George Eisenbarth and Matthias von Herrath

Diabetes 2012 May; 61 (5): 1169-1179. https://doi.org/10.2337/db11-0671
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Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice
Shounan Yi, Ming Ji, Jingjing Wu, Xiaoqian Ma, Peta Phillips, Wayne J. Hawthorne and Philip J. O’Connell

Diabetes 2012 May; 61 (5): 1180-1191. https://doi.org/10.2337/db11-1306
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Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 DiabetesA Twin and Population Study
Huriya Beyan, Harriette Riese, Mohammed I. Hawa, Guisi Beretta, Howard W. Davidson, John C. Hutton, Huibert Burger, Michael Schlosser, Harold Snieder, Bernhard O. Boehm and R. David Leslie

Diabetes 2012 May; 61 (5): 1192-1198. https://doi.org/10.2337/db11-0971
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The Radioprotective 105/MD-1 Complex Contributes to Diet-Induced Obesity and Adipose Tissue Inflammation
Yasuharu Watanabe, Tomoya Nakamura, Sho Ishikawa, Shiho Fujisaka, Isao Usui, Koichi Tsuneyama, Yoshinori Ichihara, Tsutomu Wada, Yoichiro Hirata, Takayoshi Suganami, Hirofumi Izaki, Shizuo Akira, Kensuke Miyake, Hiro-omi Kanayama, Michio Shimabukuro, Masataka Sata, Toshiyasu Sasaoka, Yoshihiro Ogawa, Kazuyuki Tobe, Kiyoshi Takatsu and Yoshinori Nagai

Diabetes 2012 May; 61 (5): 1199-1209. https://doi.org/10.2337/db11-1182

Pathophysiology

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Short-Term Hyperinsulinemia and Hyperglycemia Increase Myocardial Lipid Content in Normal Subjects
Yvonne Winhofer, Martin Krššák, Draženka Janković, Christian-Heinz Anderwald, Gert Reiter, Astrid Hofer, Siegfried Trattnig, Anton Luger and Michael Krebs

Diabetes 2012 May; 61 (5): 1210-1216. https://doi.org/10.2337/db11-1275
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The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans
Birgit Gustafson and Ulf Smith

Diabetes 2012 May; 61 (5): 1217-1224. https://doi.org/10.2337/db11-1419

Complications

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Diabetes Disrupts the Response of Retinal Endothelial Cells to the Angiomodulator Lysophosphatidic Acid
Jorge Aranda, Ruta Motiejunaite, Eunok Im and Andrius Kazlauskas

Diabetes 2012 May; 61 (5): 1225-1233. https://doi.org/10.2337/db11-1189
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Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities
Cristina Carvalho, Susana Cardoso, Sónia C. Correia, Renato X. Santos, Maria S. Santos, Inês Baldeiras, Catarina R. Oliveira and Paula I. Moreira

Diabetes 2012 May; 61 (5): 1234-1242. https://doi.org/10.2337/db11-1186

Pharmacology and Therapeutics

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The Human GLP-1 Analog Liraglutide and the PancreasEvidence for the Absence of Structural Pancreatic Changes in Three Species
Niels C.B. Nyborg, Anne-Marie Mølck, Lars W. Madsen and Lotte Bjerre Knudsen

Diabetes 2012 May; 61 (5): 1243-1249. https://doi.org/10.2337/db11-0936
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Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the Kras^G12D Mouse Model
Belinda Gier, Aleksey V. Matveyenko, David Kirakossian, David Dawson, Sarah M. Dry and Peter C. Butler

Diabetes 2012 May; 61 (5): 1250-1262. https://doi.org/10.2337/db11-1109
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A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control
Vinay Bhaskar, Ira D. Goldfine, Daniel H. Bedinger, Angela Lau, Hua F. Kuan, Lisa M. Gross, Masahisa Handa, Betty A. Maddux, Susan R. Watson, Shirley Zhu, Ajay J. Narasimha, Raphael Levy, Lynn Webster, Sujeewa D. Wijesuriya, Naichi Liu, Xiaorong Wu, David Chemla-Vogel, Catarina Tran, Steve R. Lee, Steve Wong, Diane Wilcock, Mark L. White and John A. Corbin

Diabetes 2012 May; 61 (5): 1263-1271. https://doi.org/10.2337/db11-1578

Genetics/Genomes/Proteomics/Metabolomics

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Placental Adiponectin Gene DNA Methylation Levels Are Associated With Mothers’ Blood Glucose Concentration
Luigi Bouchard, Marie-France Hivert, Simon-Pierre Guay, Julie St-Pierre, Patrice Perron and Diane Brisson

Diabetes 2012 May; 61 (5): 1272-1280. https://doi.org/10.2337/db11-1160
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Peripheral Blood Monocyte Gene Expression Profile Clinically Stratifies Patients With Recent-Onset Type 1 Diabetes
Katharine M. Irvine, Patricia Gallego, Xiaoyu An, Shannon E. Best, Gethin Thomas, Christine Wells, Mark Harris, Andrew Cotterill and Ranjeny Thomas

Diabetes 2012 May; 61 (5): 1281-1290. https://doi.org/10.2337/db11-1549
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No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Robert A. Scott, Audrey Y. Chu, Niels Grarup, Alisa K. Manning, Marie-France Hivert, Dmitry Shungin, Anke Tönjes, Ajay Yesupriya, Daniel Barnes, Nabila Bouatia-Naji, Nicole L. Glazer, Anne U. Jackson, Zoltán Kutalik, Vasiliki Lagou, Diana Marek, Laura J. Rasmussen-Torvik, Heather M. Stringham, Toshiko Tanaka, Mette Aadahl, Dan E. Arking, Sven Bergmann, Eric Boerwinkle, Lori L. Bonnycastle, Stefan R. Bornstein, Eric Brunner, Suzannah J. Bumpstead, Soren Brage, Olga D. Carlson, Han Chen, Yii-Der Ida Chen, Peter S. Chines, Francis S. Collins, David J. Couper, Elaine M. Dennison, Nicole F. Dowling, Josephine S. Egan, Ulf Ekelund, Michael R. Erdos, Nita G. Forouhi, Caroline S. Fox, Mark O. Goodarzi, Jürgen Grässler, Stefan Gustafsson, Göran Hallmans, Torben Hansen, Aroon Hingorani, John W. Holloway, Frank B. Hu, Bo Isomaa, Karen A. Jameson, Ingegerd Johansson, Anna Jonsson, Torben Jørgensen, Mika Kivimaki, Peter Kovacs, Meena Kumari, Johanna Kuusisto, Markku Laakso, Cécile Lecoeur, Claire Lévy-Marchal, Guo Li, Ruth J.F. Loos, Valeri Lyssenko, Michael Marmot, Pedro Marques-Vidal, Mario A. Morken, Gabriele Müller, Kari E. North, James S. Pankow, Felicity Payne, Inga Prokopenko, Bruce M. Psaty, Frida Renström, Ken Rice, Jerome I. Rotter, Denis Rybin, Camilla H. Sandholt, Avan A. Sayer, Peter Shrader, Peter E.H. Schwarz, David S. Siscovick, Alena Stančáková, Michael Stumvoll, Tanya M. Teslovich, Gérard Waeber, Gordon H. Williams, Daniel R. Witte, Andrew R. Wood, Weijia Xie, Michael Boehnke, Cyrus Cooper, Luigi Ferrucci, Philippe Froguel, Leif Groop, W.H. Linda Kao, Peter Vollenweider, Mark Walker, Richard M. Watanabe, Oluf Pedersen, James B. Meigs, Erik Ingelsson, Inês Barroso, Jose C. Florez, Paul W. Franks, Josée Dupuis, Nicholas J. Wareham and Claudia Langenberg

Diabetes 2012 May; 61 (5): 1291-1296. https://doi.org/10.2337/db11-0973
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Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation
Liling L. Warren, Li Li, Matthew R. Nelson, Margaret G. Ehm, Judong Shen, Dana J. Fraser, Jennifer L. Aponte, Keith L. Nangle, Andrew J. Slater, Peter M. Woollard, Matt D. Hall, Simon D. Topp, Xin Yuan, Lon R. Cardon, Stephanie L. Chissoe, Vincent Mooser, Andrew D. Morris, Colin N.A. Palmer, John R. Perry, Timothy M. Frayling, John C. Whittaker and Dawn M. Waterworth

Diabetes 2012 May; 61 (5): 1297-1301. https://doi.org/10.2337/db11-0985

Erratum

Open Access

Diabetes 2012 May; 61 (5): 1302-1304. https://doi.org/10.2337/db12-er05

Issues and Events

Open Access
Issues and Events
Diabetes 2012 May; 61 (5): 1305. https://doi.org/10.2337/db12-ie05

Diabetes Digests

Open Access
Highlights From the Latest in Diabetes Research
Diabetes 2012 May; 61 (5): 1306-1307. https://doi.org/10.2337/db12-dd05

Online Letters to the Editor

Open Access
Comment on: Marquez et al. Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk. Diabetes 2012;61:524–530
Antonio Brunetti, Eusebio Chiefari, Clive R. Pullinger, Sinan Tanyolac, Daniela Foti, Vincent Durlach and Ira D. Goldfine

Diabetes 2012 May; 61 (5): e3. https://doi.org/10.2337/db12-0051

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Table of Contents

Perspectives in Diabetes

Commentaries

Methodology Review

Metabolism

Signal Transduction

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics/Genomes/Proteomics/Metabolomics

Erratum

Issues and Events

Diabetes Digests

Online Letters to the Editor

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