Comment on: Marquez et al. Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk. Diabetes 2012;61:524–530
- Antonio Brunetti1,
- Eusebio Chiefari1,
- Clive R. Pullinger2,
- Sinan Tanyolac3,
- Daniela Foti1,
- Vincent Durlach4 and
- Ira D. Goldfine5
- 1Department of Health Sciences, University of Catanzaro “Magna Græcia,” Catanzaro, Italy
- 2Cardiovascular Research Institute and Department of Physiological Nursing, School of Nursing, University of California San Francisco, San Francisco, California
- 3Department of Endocrinology, Diabetes and Metabolism, Vehbi Koç Foundation American Hospital, Istanbul, Turkey
- 4Pôle thoracique et cardio-vasculaire, Hôpital Robert Debré, Centre Hospitalo-Universitaire, Reims, France
- 5Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, California
- Corresponding author: Antonio Brunetti, .
We read with interest the article in Diabetes by Marquez et al. (1) that followed a recent abstract from this group (2) in which it reported that HMGA1 gene variants were associated with type 2 diabetes (T2D). It is surprising, therefore, that the same authors now conclude the opposite (1). We have described four functional HMGA1 variants that were associated with T2D in ∼10% of 3,278 Italian patients (3) and confirmed this finding in two other populations—U.S. and French (3).
We have no explanation as to why the Marquez group does not agree with itself. There are several explanations, however, for the discrepancies between our studies …