Monounsaturated Fatty Acids Prevent the Aversive Effects of Obesity on Locomotion, Brain Activity, and Sleep Behavior

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FIG. 1.
FIG. 1.

Metabolic consequences of fat-enriched diets in C57BL/6 mice. C57BL/6 mice were weaned on MUFA-enriched (gray), SFA-enriched (black), or chow (white) diet for 8 weeks. A and B: SFA- and MUFA-fed mice displayed significantly increased body weight gain after 6 weeks compared with the control group (n = 15–30/group; *P < 0.05, ***P < 0.001). C: Food intake in kcal/day for control (white bars), MUFA (gray bars), and SFA (black bars) groups during the feeding period. Asterisks mark significance to controls (***P < 0.001 and **P < 0.005). D: Intraperitoneally injected glucose during a GTT was cleared slower and less effectively in SFA-fed mice (black circles) compared with controls (white circles) and MUFA-fed animals (gray circles) (n = 15–30/group; *P < 0.05 and **P < 0.005 to controls; #P < 0.05 to MUFA group). E: Attenuated serum insulin concentration during the GTT in SFA-fed mice (black circles). Increased fed (F) and fasted (G) serum insulin concentrations in the SFA-diet animal group (*P < 0.05 and **P < 0.005). H: Blood glucose concentrations from tail bleed during an intraperitoneal insulin tolerance test in control (white circles), MUFA (gray circles), and SFA (black circles) mice (n =15–30/group; *P < 0.05 SFA group to controls). Data are presented as mean ± SEM.

This Article

  1. Diabetes vol. 61 no. 7 1669-1679