Monounsaturated Fatty Acids Prevent the Aversive Effects of Obesity on Locomotion, Brain Activity, and Sleep Behavior

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FIG. 6.
FIG. 6.

Metabolic consequences of fat-enriched diets in body weight–matched C57BL/6 mice. C57BL/6 mice were weaned on MUFA-enriched (gray), SFA-enriched (black), or chow (white) diet for 8 weeks and body weight–matched animals of all diet groups were selected (n = 4/group). A: Intraperitoneally injected glucose during a GTT was cleared slower and less effectively in SFA-fed mice (black circles) compared with controls (white circles) and MUFA-fed animals (gray circles) (#P < 0.05 to MUFA group). B: Increased fasted blood glucose levels in SFA-fed mice compared with MUFA- (P = 0.05) and chow-fed animals. C: Slightly increased serum insulin concentration during the GTT in MUFA-fed mice (gray circles). D: Increased fasted serum insulin concentrations in the SFA-diet animal group (P = 0.137 to control and MUFA group). E: Increased homeostasis model assessment of insulin resistance (HOMA-IR) in SFA-fed mice (P = 0.1285 to control and P = 0.1137 to MUFA-fed group). F: Analysis of basal power spectral density (indicated for delta [0.5–4 Hz], theta [4–8 Hz], alpha [8–12 Hz], and beta [12–30 Hz] frequencies) using FFT and estimated by ECoG in MUFA- (gray bars), SFA- (black bars), and chow-fed (white bars) animals. Basal ECoG measurements were conducted during a 4-day period (**P < 0.005 and ***P < 0.001 compared with controls; ###P < 0.001 between fat-enriched diet groups). Data are presented as mean ± SEM.

This Article

  1. Diabetes vol. 61 no. 7 1669-1679