Monounsaturated Fatty Acids Prevent the Aversive Effects of Obesity on Locomotion, Brain Activity, and Sleep Behavior

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FIG. 7.
FIG. 7.

Effect of SFA- and MUFA-enriched diet on intracerebroventricular insulin–stimulated cortical activity of body weight–matched mice. ECoG analysis in the 120-min postinjection period after an acute intracerebroventricular insulin application of delta (0.5–4 Hz) (A), theta (4–8 Hz) (B), alpha (8–12 Hz) (C), and beta (12–30 Hz) (D) frequencies of MUFA-fed (gray circles/bars, n = 4), SFA-fed (black circles/bars, n = 3), and control animals (white circles/bars, n = 4). Significance is indicated for fat-enriched diets to controls: *P < 0.05, **P < 0.005, and ***P < 0.001 between fat-enriched diet groups and #P < 0.05 and ###P < 0.001; and intracerebroventricular insulin to vehicle within diet group: P < 0.05 and •••P < 0.001. Data are mean ± SEM.

This Article

  1. Diabetes vol. 61 no. 7 1669-1679