Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse

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FIG. 3.
FIG. 3.

Analysis of plasma insulin oscillations. A: Representative time courses of plasma insulin levels from a Cx36+/+ mouse (trace iii in Fig. 2A) together with pulse analysis, which is offset for clarity. B: Representative time courses of plasma insulin levels from a Cx36−/− mouse (trace iii in Fig. 2B) together with pulse analysis, as in A. C: Mean time interval between consecutive pulses for Cx36+/+ and Cx36−/− mice, 0 (T0) or 40 min (T40) after glucose infusion. n = 5 and 10 Cx36+/+ mice and 5 and 8 Cx36−/− mice in the T0 and T40 groups, respectively. D: Pulse regularity, defined by the SD of pulse interval in each time course for Cx36+/+ and Cx36−/− mice, as in C. E: Mean pulse area for Cx36+/+ and Cx36−/− mice, as in C. F: Mean pulse amplitude above basal levels for Cx36+/+ and Cx36−/− mice, as in C. *, significant difference (P ≤ 0.05, Student t test) comparing each measurement in Cx36+/+ and Cx36−/− mice.

This Article

  1. Diabetes vol. 61 no. 7 1700-1707