In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

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FIG. 8.
FIG. 8.

Impaired exocytotic responses in FAK-deficient β-cells. A: Representative capacitance responses elicited from single β-cells from RIPcre+fak+/+ and RIPcre+fakfl/fl mice in response to a series of ten 500-ms depolarizations from −70 to 0 mV. B: Averaged data demonstrates an impaired exocytotic response in β-cells from the RIPcre+fakfl/fl mice (●) compared with those from RIPcre+fak+/+ mice (○); n = 18–24 β-cells from three mice of each genotype. All mice used in experiments were between 4 and 8 weeks of age. *P < 0.05; **P < 0.01. Results represent mean ± SE. +,+/+, RIPcre+fak+/+; +,−/−, RIPcre+fakfl/fl.

This Article

  1. Diabetes vol. 61 no. 7 1708-1718