ZnT8 Is a Major CD8+ T Cell–Recognized Autoantigen in Pediatric Type 1 Diabetes
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ELISpot responses of adult type 1 diabetic patients and control subjects to ZnT8 peptides. ELISpot results are represented
as multiples of the SD for the individual assay after subtraction of the mean basal spot number measured in the presence of
solvent; for example, a value of 10 indicates that the spot number corresponded to (basal mean for the patient tested) + 10
SD. Each dot corresponds to an individual result for the peptide indicated on the x-axis. Data represent ELISpot results for six HLA-A2+ diabetic patients and three HLA-A2+ healthy control subjects.