Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

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FIG. 4.
FIG. 4.

Transgenic (Tg) mice showed decreased hepatic fat accumulation compared with wild-type (Wt) mice. A: Representative sections of liver, stained with hematoxylin-eosin (original magnification ×400). B: Liver triglyceride content was determined as indicated in research design and methods. Srebf1 (C) and Fasn (D) liver expression were analyzed by quantitative real-time PCR and normalized by 36B4 expression. Triglyceride content was determined in muscle (E), kidney (F), and heart (G) as indicated in research design and methods. Data represent the mean ± SEM of at least 10 animals per group. *P < 0.05 vs. Wt HFD. $P < 0.05 vs. Wt chow. $$P < 0.01 vs. Wt chow. ^^P < 0.01 vs. Tg chow. (A high-quality digital representation of this figure is available in the online issue.)

This Article

  1. Diabetes vol. 61 no. 7 1801-1813