Levels of circulating metabolites and blood pressure were determined in transgenic (Tg) and wild-type (Wt) mice fed chow and
HFD. Serum levels of FFAs (A), glycerol (B), triglycerides (C), total cholesterol (D), and HDL cholesterol (E) were analyzed, and systolic and diastolic blood pressure (F) was determined as indicated in research design and methods. Data represent the mean ± SEM of at least 10 animals per group. *P < 0.05 vs. Wt HFD. **P < 0.01 vs. Wt HFD. $$P < 0.01 vs. Wt chow. ^^P < 0.01 vs. Tg chow.