Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance

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FIG. 7.
FIG. 7.

Study of WAT and BAT infiltrates. A: MAC-2 immunohistochemistry was performed in WAT and BAT of wild-type (Wt) and transgenic (Tg) mice (representative images at original magnification ×200). Red arrows indicate MAC-2 signal. Flow cytometry analysis of CD11b+ F480+ (B), MHCII+ CD11b+ (C), MHCII+ CD11c+ (D), CD11chigh F4/80+ (E), and MGL1+ CD11b+ (F) cells in WAT. The stroma vascular fraction from Wt and Tg mice fed chow or an HFD was double incubated with corresponding antibodies to detect different cell populations. Data represent the mean ± SEM of at least five animals for each group. *P < 0.05 vs. Wt HFD. **P < 0.01 vs. Wt HFD. $P < 0.05 vs. Wt chow. $$P < 0.01 vs. Wt chow. (A high-quality digital representation of this figure is available in the online issue.)

This Article

  1. Diabetes vol. 61 no. 7 1801-1813