Insulin Rescues Impaired Spermatogenesis via the Hypothalamic-Pituitary-Gonadal Axis in Akita Diabetic Mice and Restores Male Fertility

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FIG. 2.
FIG. 2.

Akita mice have impaired sperm motility and morphology. A: CASA of caudal sperm from wild-type (WT), Akita heterozygous, and Akita homozygous mice reveals that Akita homozygous sperm has a lower percentage of motile sperm. Akita heterozygous mice also display poorer CASA parameters (n = 3 experiments). **P < 0.01. B: Electron micrographs of wild-type and Akita homozygous sperm. Sperm cells obtained from either testicular sections or the cauda epididymis lack acrosomes and often display head detachment, membrane blebbing, and abnormal mitochondria. um, μm.

This Article

  1. Diabetes vol. 61 no. 7 1869-1878