Akita mice have impaired sperm motility and morphology. A: CASA of caudal sperm from wild-type (WT), Akita heterozygous, and Akita homozygous mice reveals that Akita homozygous sperm
has a lower percentage of motile sperm. Akita heterozygous mice also display poorer CASA parameters (n = 3 experiments). **P < 0.01. B: Electron micrographs of wild-type and Akita homozygous sperm. Sperm cells obtained from either testicular sections or the
cauda epididymis lack acrosomes and often display head detachment, membrane blebbing, and abnormal mitochondria. um, μm.