Insulin Rescues Impaired Spermatogenesis via the Hypothalamic-Pituitary-Gonadal Axis in Akita Diabetic Mice and Restores Male Fertility

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FIG. 8.
FIG. 8.

Serum testosterone and LH are decreased in Akita mice. LH and testosterone are significantly decreased in Akita heterozygotes and homozygotes. Insulin pellet treatment reversed this trend (n = 4). *P < 0.05, **P < 0.01. WT, wild type; ins, insulin. (A high-quality color representation of this figure is available in the online issue.)

This Article

  1. Diabetes vol. 61 no. 7 1869-1878