PTGS-2–PTGER2/4 Signaling Pathway Partially Protects From Diabetogenic Toxicity of Streptozotocin in Mice

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FIG. 1.
FIG. 1.

Expression of PTGS isoforms in pancreas. A: Expression of PTGS mRNA in pancreas and isolated islets from mouse. RNA was isolated from pancreas and from isolated islets, and mRNA expression for PTGS-1 and PTGS-2 was analyzed by PCR in comparison with SLC2A2 and proinsulin mRNA expression. B: Effect of STZ on pancreatic expression of PTGS-1 and PTGS-2. STZ or vehicle was injected on day 1. On day 4, pancreata were prepared, and mRNA expression for PTGS-1 and PTGS-2 was analyzed by PCR in comparison with β-actin mRNA expression. CTRL, wild-type mice. Data are shown as mean ± SEM; n = 3. *P < 0.05.

This Article

  1. Diabetes vol. 61 no. 7 1879-1887