PTGS-2–PTGER2/4 Signaling Pathway Partially Protects From Diabetogenic Toxicity of Streptozotocin in Mice

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FIG. 2.
FIG. 2.

Hyperglycemic effect of STZ in PTGS-deficient mice. A: Hyperglycemic effect of high dose of STZ. STZ (200 mg/kg BW) or vehicle was given intraperitoneally to wild-type mice (CTRL) and PTGS-1−/−, PTGS-2−/−, and wild-type mice treated with PTGS-2 inhibitor SC-236. On experimental day 4, blood glucose concentrations were measured by glucose meter. Data are shown as mean ± SEM; n = 6. *P < 0.05; #P < 0.05 vs. STZ-treated CTRL. B: Hyperglycemic effect of multiple low doses of STZ. STZ (40 mg/kg BW) was given intraperitoneally once daily for 5 days to CTRL, PTGS-1−/−, and PTGS-2−/− mice. Blood glucose concentrations were measured before STZ application (day 0) and on days 5 and 23. Data are shown as mean ± SEM; n = 6. *P < 0.05 vs. day 0.

This Article

  1. Diabetes vol. 61 no. 7 1879-1887