PTGS-2–PTGER2/4 Signaling Pathway Partially Protects From Diabetogenic Toxicity of Streptozotocin in Mice

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FIG. 4.
FIG. 4.

Toxicity of STZ in PTGS-deficient mice. A: Kaplan-Meier survival analysis of STZ-treated PTGS-deficient mice. Wild-type mice (CTRL) were treated with SC-236 or vehicle 1 day before single application of STZ (200 mg/kg BW). PTGS-1−/− and PTGS-2−/− were only treated with STZ (200 mg/kg BW). Mice were kept under standard conditions for 10 days. Data are shown as mean ± SEM; n = 10. B: Plasma elimination of STZ. Wild-type mice were treated with vehicle or SC-236 24 and 4 h before application of STZ. PTGS-2−/− were only treated with STZ (200 mg/kg BW). Plasma samples were collected 30 min, 60 min, and 12 h later. Amount of STZ was determined by LC-ESI-MS/MS. Data are shown as mean ± SEM; n = 5. No significant differences between the groups were observed at the indicated time points.

This Article

  1. Diabetes vol. 61 no. 7 1879-1887