Comment on: Winkler et al. Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis. Diabetes 2012;61:513–523

  1. Ranjeet Singh Mahla
  1. Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India
  1. Corresponding author: Ranjeet Singh Mahla, mahlaranjeet{at}ccmb.res.in.

Histone deacetylase 6 (HDAC 6) is known to play a critical role in histone modification and transcription regulation of a wide variety of genes involved in cell cycle regulation and cell proliferation, migration, and development. Recently, Winkler et al. (1) analyzed the role of HDAC6 in regulation of metabolism-mediating transcription of gluconeogenic genes G6P, FBP, PEPCK, and PCX …

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