Why Do SGLT2 Inhibitors Inhibit Only 30–50% of Renal Glucose Reabsorption in Humans?

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FIG. 3.
FIG. 3.

Schematic PK/PD graphs of empagliflozin (BI 10773). UGE rate–time profiles are shown in dotted line (10 mg-PD), dashed line (100 mg-PD), and dashed-dotted line (400 mg-PD). Plasma concentration–time profiles are shown in solid lines. Three representative doses are shown: 10, 100, and 400 mg. Conc., concentration. Modified from Port et al. (22) and Dugi and Mark (26).

This Article

  1. Diabetes vol. 61 no. 9 2199-2204