Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652

  1. Subrata Chowdhury
  1. From the Fraser Laboratories for Diabetes Research, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
  1. Corresponding author: Jun-Li Liu, jun-li.liu{at}

Turban et al. (1) recently reported a surprise finding that moderately elevated 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expression in the pancreatic β-cells promoted a compensation against high-fat (HF) diet–induced β-cell failure because glucocorticoids are well established to impair insulin secretion and cause β-cell death and insulin resistance in key insulin targets. Rather than accepting the …

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