Bcl-2 and Bcl-xL Suppress Glucose Signaling in Pancreatic β-Cells

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FIG. 7.
FIG. 7.

Improved glucose tolerance in Bcl-x βKO mice. A: In vivo insulin secretion following intraperitoneal injection of 2 g/kg glucose in 10–12-week-old Bcl-x WT and βKO littermate mice (n = 5). B and C: Intraperitoneal glucose tolerance tests of Bcl-x βKO and WT mice using 2 and 0.5 g/kg glucose doses (n = 7 and n = 8, respectively; *P < 0.05). D: Area under the curve analysis of glucose profiles in panels B and C. E: Insulin tolerance test of Bcl-x WT and βKO mice (n = 5). IPGTT, intraperitoneal glucose tolerance test; mM, mmol/L. (A high-quality color representation of this figure is available in the online issue.)

This Article

  1. Diabetes vol. 62 no. 1 170-182