Comment on: Straznicky et al. Neuroadrenergic Dysfunction Along the Diabetes Continuum: A Comparative Study in Obese Metabolic Syndrome Subjects. Diabetes 2012;61:2506–2516

  1. Simona Frontoni
  1. From Endocrinology, Diabetes and Metabolism, S. Giovanni Calibita Fatebenefratelli Hospital, Rome, Italy; and the Department of System Medicine, University of Rome Tor Vergata, Rome, Italy
  1. Corresponding author: Simona Frontoni, frontoni{at}

In the recent article by Straznicky et al. (1), the authors demonstrate that the onset of diabetes is associated with increased central sympathetic outflow, altered norepinephrine disposition, and blunted sympathetic responsiveness to carbohydrates. In fact, insulin resistance highly correlated with neuroadrenergic function, as shown by the independent correlation of insulin-stimulated glucose uptake (M/I) with whole-body norepinephrine spillover. Muscle sympathetic nerve activity (MSNA), on the contrary, failed to correlate with insulin resistance. This apparently surprising result can, however, find a logical explanation (2), which actually reinforces the data of Straznicky et al. Sympathetic overactivity, similarly …

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