Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813

  1. Yaowu Zheng
  1. From the Transgenic Animal Research Center, School of Life Science, Northeast Normal University, Changchun, Jilin, China
  1. Corresponding author: Yaowu Zheng, zhengyw442{at}

Vascular endothelial growth factor (VEGF) has been investigated for playing a role in energy metabolism. Bosch and colleagues (1) studied the transgenic mouse model of adipose tissue–specific VEGF overexpression (aP2VEGF). It was firm that VEGF expression and blood vessels were increased in adipose tissue of the transgenic mice. The demonstration of aP2VEGF mice protecting against diet-induced obesity and …

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