Response to Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813
We appreciate the interest of Drs. Lu and Zheng (1) in our work showing that adipose tissue overexpression of vascular endothelial growth factor (VEGF) in transgenic mice protects against diet-induced obesity and insulin resistance (2). We agree that changes in VEGF expression may also play a role in the development of diseases such as obesity, diabetes, or cancer and that the underlying mechanisms are complex, as reflected by recent literature. …