Response to Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813

Ivet Elias; Sylvie Franckhauser; Fatima Bosch

doi:10.2337/db12-1274

Online Letters to the Editor

Response to Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813

Ivet Elias¹,²,³,
Sylvie Franckhauser¹,³ and
Fatima Bosch¹,²,³

From the ¹Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Barcelona, Spain
the ²Departments of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
and the ³CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

Corresponding author: Fatima Bosch, fatima.bosch{at}uab.es.

Diabetes 2013 Jan; 62(1): e4-e4. https://doi.org/10.2337/db12-1274

We appreciate the interest of Drs. Lu and Zheng (1) in our work showing that adipose tissue overexpression of vascular endothelial growth factor (VEGF) in transgenic mice protects against diet-induced obesity and insulin resistance (2). We agree that changes in VEGF expression may also play a role in the development of diseases such as obesity, diabetes, or cancer and that the underlying mechanisms are complex, as reflected by recent literature. …

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