Response to Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813
- From the 1Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Barcelona, Spain
- the 2Departments of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
- and the 3CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain
- Corresponding author: Fatima Bosch, .
We appreciate the interest of Drs. Lu and Zheng (1) in our work showing that adipose tissue overexpression of vascular endothelial growth factor (VEGF) in transgenic mice protects against diet-induced obesity and insulin resistance (2). We agree that changes in VEGF expression may also play a role in the development of diseases such as obesity, diabetes, or cancer and that the underlying mechanisms are complex, as reflected by recent literature. …