Response to Comment on: Elias et al. Adipose Tissue Overexpression of Vascular Endothelial Growth Factor Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes 2012;61:1801–1813

  1. Fatima Bosch1,2,3
  1. From the 1Center of Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona, Barcelona, Spain
  2. the 2Departments of Biochemistry and Molecular Biology, School of Veterinary Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
  3. and the 3CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain
  1. Corresponding author: Fatima Bosch,{at}

We appreciate the interest of Drs. Lu and Zheng (1) in our work showing that adipose tissue overexpression of vascular endothelial growth factor (VEGF) in transgenic mice protects against diet-induced obesity and insulin resistance (2). We agree that changes in VEGF expression may also play a role in the development of diseases such as obesity, diabetes, or cancer and that the underlying mechanisms are complex, as reflected by recent literature. …

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