Comment on: Tessari et al. Roles of Insulin, Age, and Asymmetric Dimethylarginine on Nitric Oxide Synthesis In Vivo. Diabetes 2013;62:2699–2708
- 1Department of Coronary Artery Disease, the John Paul II Hospital, Cracow, Poland
- 22nd Department of Cardiology, Jagiellonian University Medical College, Cracow, Poland.
- Corresponding author: Andrzej Surdacki, .
Tessari et al. (1) elegantly demonstrated—by a precursor-product stable isotope method—independent contributions of age, type 2 diabetes, and asymmetric dimethylarginine (ADMA) to impaired conversion of 15N-labeled L-arginine into nitrite and nitrate (NOx), products of nitric oxide (NO) metabolism. Interestingly, the authors observed no associations of any parameter of NOx kinetics with insulin sensitivity by a hyperinsulinemic-euglycemic clamp technique (1).
Our group was the first to report elevated plasma …