Comment on: Tessari et al. Roles of Insulin, Age, and Asymmetric Dimethylarginine on Nitric Oxide Synthesis In Vivo. Diabetes 2013;62:2699–2708

  1. Andrzej Surdacki2
  1. 1Department of Coronary Artery Disease, the John Paul II Hospital, Cracow, Poland
  2. 22nd Department of Cardiology, Jagiellonian University Medical College, Cracow, Poland.
  1. Corresponding author: Andrzej Surdacki, surdacki.andreas{at}

Tessari et al. (1) elegantly demonstrated—by a precursor-product stable isotope method—independent contributions of age, type 2 diabetes, and asymmetric dimethylarginine (ADMA) to impaired conversion of 15N-labeled L-arginine into nitrite and nitrate (NOx), products of nitric oxide (NO) metabolism. Interestingly, the authors observed no associations of any parameter of NOx kinetics with insulin sensitivity by a hyperinsulinemic-euglycemic clamp technique (1).

Our group was the first to report elevated plasma …

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