Response to Comment on: Tessari et al. Roles of Insulin, Age, and Asymmetric Dimethylarginine on Nitric Oxide Synthesis In Vivo. Diabetes 2013;62:2699–2708

  1. Paolo Tessari
  1. Metabolism Division, Department of Medicine, University of Padova, Padova, Italy.
  1. Corresponding author: Paolo Tessari, paolo.tessari{at}

I have read with interest the comment letter by Kruszelnicka et al. (1) to our article recently published in Diabetes (2). Their letter contains useful observations and raises interesting questions. One is about the dissociation of the metabolic sensitivity to insulin from endothelial nitric oxide (NO) release and its vascular protective effects, and the other is on the specificity of the assay of blood nitrates (both 15N-labeled and unlabeled) as indices of NO generation.

In regards to the first issue, recent work by the Accili Laboratory, commented on by Kearney (3), report data on the dissociation between …

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