Comment on: Selvin et al. sRAGE and Risk of Diabetes, Cardiovascular Disease, and Death. Diabetes 2013;62:2116–2121

  1. Sho-ichi Yamagishi
  1. Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan.
  1. Corresponding author: Sho-ichi Yamagishi, shoichi{at}

I have recently read an article by Selvin et al. (1) that showed that low plasma levels of soluble circulating receptor for advanced glycation end products (sRAGEs) at baseline were independently associated with the risk of coronary heart disease (CHD) and all-cause mortality during a median of 18 years of follow-up in a community-based population. I totally agree with the authors’ opinions that low sRAGE level is a marker of future chronic disease risk and mortality in the generation population. However, I think it unlikely that sRAGE could work as a “sponge” for AGEs in humans and …

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