Comment on: Sitnick et al. Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity. Diabetes 2013;62:3350–3361

  1. Dominique Langin
  1. INSERM UMR1048, Institute of Metabolic and Cardiovascular Diseases, Obesity Research Laboratory, and Paul Sabatier University, Toulouse, France
  1. Corresponding author: Cedric Moro, cedric.moro{at}inserm.fr.

Sitnick et al. (1) provide compelling evidence that skeletal muscle–specific modulations of adipose triglyceride lipase (ATGL) expression in vivo in mice impacts intramyocellular triacylglycerol (IMTG) content with no measurable effects on other lipid species (diacylglycerols [DAG], ceramides, and long-chain acyl-coenzyme A) and insulin sensitivity. The authors speculate that the fatty acid (FA) cycle observed in cardiac muscle, with FA largely trafficking through IMTG before …

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