Response to Comment on: Sukumar et al. Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance–Related Endothelial Cell Dysfunction. Diabetes 2013;62:2130–2134

  1. Mark T. Kearney
  1. Division of Cardiovascular and Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, West Yorkshire, U.K.
  1. Corresponding author: Mark T. Kearney, m.t.kearney{at}leeds.ac.uk.

We would like to thank Drs. Jandeleit-Dahm and Schmidt (1) for their interesting comments regarding our study examining the role of the Nox2 isoform of NADPH oxidase in insulin resistance–related endothelial cell dysfunction (2). We would also like to congratulate them on their own elegant and comprehensive piece of work examining the role of the Nox isoforms Nox1, Nox2, and Nox4 in the development of advanced type 1 diabetes–related atherosclerosis (3).

Based on their findings that Nox1 may be more important in diabetes-related atherosclerosis than other isoforms of NADPH oxidase, the authors raise concerns regarding our conclusions that Nox2 has a critical …

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