β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?
- 1Division of Endocrinology, Larry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California
- 2Department of Biochemistry and Molecular Biology, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California
- Corresponding author: Safia Costes, .
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- Islet pathology in TYPE 2 DIABETES
- Protein misfolding and oligomerization
- Defenses against protein misfolding and aggregation
- Defenses against protein aggregation overcome: the threshold concept
- Threshold for successful protein folding and disposal overcome: a role for β-cell mass formed in childhood?
- Threshold for successful protein folding and disposal overcome: a role for adolescence, pregnancy, and aging?
- Lessons from genetics?
- Where do oligomers form, and how do they damage cells?
- Extracellular islet amyloid as a diffusion barrier?
- Figures & Data
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