β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

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FIG. 4.
FIG. 4.

β-Cell mass growth varies widely in childhood. Postnatal expansion of β-cell number plays a major role in establishing β-cell mass in adult humans and is highly variable between individuals. Data are from Meier et al. (60). Total number of β-cells in 46 children aged 2 weeks to 21 years. Data are represented as individual data points. Individuals with high (A, blue), intermediate (B, green), and low (C, red) β-cell numbers are shown for consideration of β-cell workload in response to obesity in Fig. 5.

This Article

  1. Diabetes vol. 62 no. 2 327-335