β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

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FIG. 5.
FIG. 5.

Interaction of postnatal β-cell mass and BMI on insulin and IAPP synthetic demand. Schematic representation of the risk of T2DM in individuals with high (A, blue), intermediate (B, green), and low (C, red) β-cell mass formed after postnatal growth (see Fig. 4) with consideration of their BMI. The increment in the protein synthetic burden per β-cell increases more steeply in those with low (individual C) versus a high number of β-cells (individual A). The burden placed on β-cells by obesity is thus higher in individual C, as is the risk to breach the threshold for protein folding and disposal, ultimately leading to β-cell failure in T2DM.

This Article

  1. Diabetes vol. 62 no. 2 327-335