β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

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FIG. 6.
FIG. 6.

β-Cell workload and risk of T2DM. Schematic representation of β-cell workload (in black) and β-cell work capacity (green) throughout life. β-Cell workload increases transiently during adolescence and progressively with aging. The capacity for β-cell workload is defined by the β-cell mass after the postnatal expansion (high in individual A, intermediate in individual B, and low in individual C, see Fig. 4) and β-cell ability to defend against protein misfolding (declines in all individuals with aging). T2DM risk increases when workload exceeds capacity (light orange), in adolescence and early adult life in C, later in B, and only with advanced age in A.

This Article

  1. Diabetes vol. 62 no. 2 327-335