Pathogenesis of Aβ+ Ketosis-Prone Diabetes

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FIG. 6.
FIG. 6.

Schematic representation of metabolic defects in KPD as revealed by a combination of metabolomics and kinetics. Short black arrows represent increase or decrease in a metabolite measured in the metabolomics survey, whereas short white arrows represent increase, decrease, or no change in a metabolite measured in the kinetic studies. Lipid bilayer indicates the boundary of a liver cell. Dashed long arrows indicate decreased flux, and solid long arrows indicate increased flux. See text for details. alpha-KG, alpha-ketoglutarate; CPS, carbamoyl phosphate synthetase; GDH, glutamate dehydrogenase.

This Article

  1. Diabetes vol. 62 no. 3 912-922