What’s the Time? Does the Artificial Pancreas Need to Know?
- Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
- Corresponding author: Susanne E. la Fleur, .
The development of a closed-loop artificial pancreas (AP) represents a major technological effort that aims to improve glucose control, prevent complications, and decrease disease burden for patients with diabetes. An AP consists of three components: 1) a subcutaneous glucose monitor, 2) a subcutaneous insulin pump, and 3) an automated control algorithm (Fig. 1) (1,2). Until recently, clinical trials investigating AP function were limited to controlled, in-hospital settings (1,3). However, several recent studies showed that an AP can maintain (4) or even improve (5) glycemic control outside of the hospital.
Several types of control algorithms have been developed. On the one hand, proportional-integrative derivative algorithms use a classical …