Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

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FIG. 1.
FIG. 1.

Hepatic pyruvate carboxylase (PC) protein expression levels relate to glycemic levels in humans. Hepatic PC mRNA expression in human livers compared with fasting plasma glucose concentration (A) and HbA1c (B). Hepatic PC protein expression in human livers compared with fasting plasma glucose concentration (C) and HbA1c, along with representative bands (D). PC mRNA and protein are expressed as a relative increase to the lowest expression in the data set (n = 20). VDAC, voltage-dependent anion channel.

This Article

  1. Diabetes vol. 62 no. 7 2183-2194