Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

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FIG. 2.
FIG. 2.

Pyruvate carboxylase (PC) ASO decreased PC expression in liver and epididymal adipose tissue. PC mRNA in liver (A) and epididymal adipose tissue (B). PC protein, with representative bands, is shown in liver (C) and epididymal adipose tissue (D). **P < 0.01 and ***P < 0.001 compared with control ASO group in the same diet condition. #P < 0.05 and ###P < 0.001 compared with control ASO group in regular chow-fed condition (n = 3–4 per group in regular chow-fed condition; n = 9–10 per group in HFF condition). All rats were killed and tissues were taken at 4 weeks of treatment. VDAC, voltage-dependent anion channel.

This Article

  1. Diabetes vol. 62 no. 7 2183-2194