Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 3.
FIG. 3.

Pyruvate carboxylase (PC) ASO decreased plasma glucose concentration and did not decrease insulin secretion. Fasting plasma glucose (A) and insulin concentration (B) in the regular chow-fed rats (n = 7–10 per group). C: Ad lib–fed plasma glucose concentration in the regular chow-fed rats (n = 5 per group). Results of mixed-meal tolerance test in the regular chow-fed rats for plasma glucose (D), plasma insulin (E), and plasma C-peptide (F) (n = 7–10). G: Pyruvate tolerance test in the regular chow-fed and HFF rats. ○ are control ASO and ● are PC ASO in regular chow-fed rats (both n = 9). △ are control ASO and ▲ are PC ASO in HFF rats (both n = 8). *P < 0.05, **P < 0.01, and ***P < 0.001 between control and PC ASO in regular chow-fed rats; ##P < 0.01 and ###P < 0.001 between control and PC ASO in HFF rats. Experiments were done at 4–5 weeks of treatment.

This Article

  1. Diabetes vol. 62 no. 7 2183-2194