Pyruvate carboxylase (PC) ASO reduced adiposity and hepatic steatosis in HFF rats. A: Body weight (BW) time course in regular chow-fed (n = 10–11 per group) and HFF rats (n = 12 per group). Epididymal adipose tissue weight (B), hepatic triglyceride content (C), and muscular triglyceride content (D) at 4 weeks of treatment in HFF rats (n = 9–10 per group). *P < 0.05 and **P < 0.01 compared with control ASO group in HFF condition. RC, regular chow.