Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

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FIG. 6.
FIG. 6.

Pyruvate carboxylase (PC) ASO decreased hepatic DAG content and PKCε activation and increased hepatic Akt phosphorylation in HFF rats. A: Hepatic DAG content (n = 9–10 per group). *P < 0.05 compared with control ASO group. B: PKCε activation. The average of control ASO group was set as 1 (n = 5 per group). GAPDH, glyceraldehyde-3-phosphate dehydrogenase. $$P < 0.001 compared with control ASO group. C: Akt phosphorylation (Ser473). The average expression of control ASO group in the basal condition was set as 1 (n = 5 per group). #P < 0.05 and ###P < 0.001 compared with control ASO group in basal condition. **P < 0.01 compared with control ASO group in clamp condition. All tissues were taken at 4–5 weeks of treatment.

This Article

  1. Diabetes vol. 62 no. 7 2183-2194