Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance
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Pyruvate carboxylase (PC) ASO reduced hepatic and adipose glycerol synthesis. A: Whole-body lipolysis as assessed by glycerol turnover in HFF rats (n = 8–9 per group). Palmitate oxidation (B) and oleate oxidation (C) assay with primary hepatocytes isolated from HFF-treated and ASO-treated rats (n = 5 per group). D: In vivo hepatic de novo fatty acid synthesis in HFF rats (n = 9–10 per group). Hepatic (E) and adipose glycerol synthesis (F) in HFF rats (n = 7–8 per group). G: Summary of this study. *P < 0.05 compared with control ASO group. All experiments were done at 4–5 weeks of treatment.