Circadian Regulation of Lipid Mobilization in White Adipose Tissues

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FIG. 4.
FIG. 4.

Circadian clock regulates lipid mobilization in WAT. A: Circadian expression profiles of genes involved in lipolysis in adipose tissue from wild-type (WT; closed circles) and ClockΔ19 (open circles) mice in DD (n = 3–4/time point). Profiles of glycerol excretion from WT (closed circles) and ClockΔ19 (open circles) epididymal WAT fat-pad explants harvested in DD (B) and LD (C) (n = 6–14/time point). D: Expression of Atgl and Hsl in WAT of WT (black bars) and Bmal1−/− (white bars) animals at 37 and 49 h after lights off (n = 2–3/time point). E: Changes in glycerol excretion from WT (black bars) and Bmal1−/− (white bars) epididymal WAT fat-pad explants harvested at 37 and 49 h after lights off (n = 8/time point). All data are shown as means ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001 by two-way ANOVA with Bonferroni posttest.

This Article

  1. Diabetes vol. 62 no. 7 2195-2203