Circadian Regulation of Lipid Mobilization in White Adipose Tissues

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FIG. 5.
FIG. 5.

Local WAT clocks regulate expression of Atgl and Hsl. A: Expression profiles of Bmal1, Per2, and Dbp mRNAs in WAT of wild-type (WT; closed circles) and ClockΔ19 (open circles) mice in DD (n = 3/time point). B: Representative baseline-subtracted luminescence recordings from epididymal, peritoneal, and subcutaneous WAT explants of PER2::LUCIFERASE circadian reporter mice. C: Rhythmic expression of Atgl and Hsl transcripts in WT (closed circles), but not ClockΔ19 (open circles), cultured fat-pad explants (n = 3/time point). D: Antiphasic expression of Per2 (open circles) and Bmal1 (closed circles) mRNAs in cultured WT fat-pad explants (n = 3/time point). All data are shown as means ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001 by two-way ANOVA with Bonferroni posttest. CPS, counts per second.

This Article

  1. Diabetes vol. 62 no. 7 2195-2203