Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes

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FIG. 3.
FIG. 3.

GFAP immunofluorescence. A: Images of representative samples of retina from a control rat (Control), a diabetic rat treated with vehicle eye drops (D-Sham), and a diabetic rat treated with SST eye drops (D-SST). In diabetic rats, the endfeet of the Müller cells showed abundant GFAP immunofluorescence (green), and the radial processed stained intensely throughout the inner retina. The topical treatment with SST prevents the glial activation. Scale bar = 50 μm. B: Quantification of glial activation based on extent of GFAP staining. INL, inner nuclear layer.

This Article

  1. Diabetes vol. 62 no. 7 2569-2578