Topical Administration of Somatostatin Prevents Retinal Neurodegeneration in Experimental Diabetes

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIG. 6.
FIG. 6.

Apoptotic signaling pathways in the neuroretina of three groups. A: Protein extracts were prepared from neuroretina. Total protein (50 μg) was used for Western blot analysis with the antibodies against FasL, caspase (casp)-8, Bid, Bim, BclxL, and active caspase-3. α-Tubulin (αtub) antibody was used as a loading control. B: Autoradiograms were quantified by scanning densitometry. C, control rats; D-Sham, diabetic rats treated with vehicle eye drops; D-SST, diabetic rats treated with SST eye drops. Results are expressed as arbitrary units of protein expression and are means ± SD. *P < 0.05, **P < 0.01, and ***P < 0.005 for diabetic mice treated with the vehicle vs. diabetic mice treated with SST eye drops.

This Article

  1. Diabetes vol. 62 no. 7 2569-2578