Apoptotic signaling pathways in the neuroretina of three groups. A: Protein extracts were prepared from neuroretina. Total protein (50 μg) was used for Western blot analysis with the antibodies
against FasL, caspase (casp)-8, Bid, Bim, BclxL, and active caspase-3. α-Tubulin (αtub) antibody was used as a loading control.
B: Autoradiograms were quantified by scanning densitometry. C, control rats; D-Sham, diabetic rats treated with vehicle eye
drops; D-SST, diabetic rats treated with SST eye drops. Results are expressed as arbitrary units of protein expression and
are means ± SD. *P < 0.05, **P < 0.01, and ***P < 0.005 for diabetic mice treated with the vehicle vs. diabetic mice treated with SST eye drops.